Endocrine Abstracts

Aim: Chemerin, a recently discovered adipokine produced by the adipose tissue and liver, along with other atherosclerosis markers, was associated lately with metabolic syndrome and acts as chemoattractant for immune cells may also regulate immune cell properties. Autoimmune Hashimoto’s thyroiditis even with sTSH levels corrected to be within the normal range values may be accompanied by dyslipidemia presenting increased total-C, TG, LDL-C, and Lp(a), all of which are pote...

Background: Hypothyroidism due to autoimmune thyroiditis leads to atherogenic lipid profile and metabolic changes. The formation of advanced glycation end products (AGEs) increases with hyperglycemia, hyperlipidemia and oxidative stress. Degradation of AGEs after AGEs-receptor 1-mediated intracellular uptake and renal clearance of soluble AGEs generated by certain cells like macrophages play a crucial role in the decrement of circulating AGEs level. Chemerin is an adipokine pr...

Background: Fibroblast growth factor 21 (FGF21) is a hormonal regulator of lipid and glucose metabolism exerting protection against atherosclerosis by multiple actions on the blood vessels, liver, and adipose tissues. Enhanced FGF21 production in diabetes and obesity reduces the level of LDL-C and triglycerides by suppression of hepatic SREBP-2. Hypothyroidism has also been shown to have unfavorable effects on atherogenesis and dyslipidemia. To date, the association of lipid p...

Background: Advanced glycation end products (AGEs) are heterogenous group of irreversible chemical moieties originated from non-enzymatic glycation and oxidation of proteins, nucleic acids, and lipids. The engagement of AGEs with their chief cellular receptor (RAGE) activates signaling pathways contributing to the progression of chronic diseases like autoimmune thyroiditis, type 2 diabetes mellitus and its complications. Soluble RAGE (sRAGE) prevents AGE-RAGE interaction in a ...

BackgroundHypothyroidism due to autoimmune thyroiditis (AITD) leads to atherogenic lipid profile and therefore might increase the cardiovascular risk of patients. Fetuin-A is a hepatokine with a role in the regulation of mineralization, metabolism and the cardiovascular system. Fetuin-A levels are known increased in obesity-linked diseases. To date, the role of fetuin-A in autoimmune thyroiditis has not been thoroughly investigated.<p class="abstext"...